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9月 7, 2026

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元記事：Older athletes show aging need not bring major losses in fitness or independence

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4月 24, 2026 医科

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前立腺がん放射線療法後の尿道狭窄に対する吻合尿道形成術は、頬粘膜移植術よりも再発リスクが低い可能性 — role: expert domain: 医療 policy: 各セクション名の直後に内容のみを出力し、空欄は禁止。余分な説明や補足は一切禁止。 outputs: – name: タイトル desc: 記事のタイトルを日本語に翻訳 – name: 要旨 desc: 記事の主要なポイントを簡潔にまとめたもの – name: 方法 desc: 研究デザイン、対象患者、評価項目などを記載 – name: 結果 desc: 主要評価項目および副次評価項目の結果を記載 – name: 考察 desc: 研究結果の解釈、臨床的意義、今後の展望などを記載 – name: 出典 desc: 研究の出典元（著者、所属、掲載誌、掲載日など）を記載 – name: 限界 desc: 研究デザイン上の限界や、結果の一般化可能性に関する制約などを記載 – name: 開示 desc: 研究資金、利益相反などに関する開示情報を記載 input: article: | TOPLINEAmong patients who developed radiation-induced bulbomembranous urethral stenosis (BMUS) after prostate cancer radiotherapy, anastomotic urethroplasty was associated with a lower risk for stricture recurrence than buccal mucosa graft (BMG) onlay.METHODOLOGYResearchers conducted a retrospective review of prospectively maintained databases from two institutions between 2001 and 2024 to compare outcomes after anastomotic urethroplasty and BMG onlay among patients with BMUS following prostate cancer radiotherapy.The study included 212 patients (median age, 68 years) who underwent either anastomotic urethroplasty (n = 163) or BMG onlay (n = 49) for radiation-induced BMUS. All patients had at least one cystoscopic evaluation after surgery and a minimum follow-up of 12 months.The primary outcome was stricture recurrence, defined as recurrent stricture < 16 Fr confirmed on cystoscopy.Secondary outcomes were 90-day complications, patient-reported satisfaction, de novo erectile dysfunction, and de novo incontinence.TAKEAWAYThe estimated risk for stricture recurrence after anastomotic urethroplasty was 3.3% at 1 year, 5.0% at 2 years, and 6.8% at 10 years, whereas the risk after BMG onlay was 17%, 18%, and 20%, respectively (log-rank P = .01).BMG onlay was associated with a higher risk for stricture recurrence in multivariable analysis (hazard ratio, 3.43; P = .046).The rates of complications, patient satisfaction, erectile dysfunction, and incontinence did not differ significantly between the two techniques.IN PRACTICE"This data suggests that anastomotic urethroplasty may be the preferred reconstructive strategy for men with radiation-induced BMUS when technically feasible. However, the choice of technique should be individualized with BMG onlay remaining an important option for longer stenoses or when excision would risk undue tension with the recognition that durability may be lower, and follow-up must be vigilant," the authors wrote.SOURCEThe study was led by Keith Rourke, MD, FRCSC, of the Department of Urology at the University of California, Irvine. It was published online on August 26 in The Journal of Urology.LIMITATIONSThe retrospective study design could have introduced selection bias and confounding by indication. The data from two high-volume centers may make it hard to apply the results to other settings.DISCLOSURESThe authors declared receiving no funding for the study and disclosed having no conflicts of interest.This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.0CreditsLead image: iStock/Getty ImagesMedscape Medical News © 2026 WebMD, LLCSend comments and news tips to news@medscape.net.Cite this: Anastomotic Urethroplasty Tied to Lower Stricture Recurrence Risk – Medscape – September 04, 2026. — 出力テンプレート: 【タイトル】【要旨】【方法】【結果】【考察】【出典】【限界】【開示】

薬物使用スクリーニングのばらつき：患者、提供者、診療所レベルでの差異を指摘

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